The laboratory has state-of-the-art imaging equipment:

  • A 9.4 Tesla, 30 cm bore research magnet equipped with a Bruker console with Paravision 6 software. The scanner is capable of a variety of state-of-art experiments including echo-planar imaging, diffusion weighted imaging, magnetization transfer imaging, and very fast imaging for monitoring contrast media uptake.
  • A positioning system attached to the magnet that uses a motor driven automatic positioning system to simplify positioning for animal throughput in routine applications. The unit includes laser positioning for accurate definition of the region of interest and a control panel with display for very precise positioning.
  • Multiple manufactured and home built coils for imaging a vast number of areas on small animal body, cells, tissues, materials, and phantoms.
  • A well-equipped small-animal surgery area and an electronics laboratory.
  • A Molecular and Physiological Imaging laboratory that the core uses for molecular biology, cell culture, contrast agent development and preparation.
  • Physiological monitoring equipment that measures respiration, blood-pressure, ECG, temperature, and oxygen.
  • A number of fast imaging computers and software programs for data analysis.
  • Upgraded equipment and the 9.4 Tesla console expands and improves the types of imaging the facility can offer. It provides a wide variety of anatomic and functional images including:

  • High resolution (as high as 100 microns in plane) T1 and T2-weighted images
  • Diffusion and Diffusion Tensor images
  • Dynamic contrast enhanced MR images
  • High resolution EPSI for improved anatomic and functional imaging
  • Magnetization Transfer images
  • Spin – tagging and angiograph
  • Time of Flight (TOF) non-contrast bright-blood method for imaging vascular system.
  • A variety of fast imaging methods including echo-planar imaging and fast spin echo imaging

    The MRIS Core Facility provides scans for the following:

  • Ex-vivo tissues and specimens
  • Cells
  • Materials, including newly developed contrast agents
  • Animal models of cancer (ie: prostate, mammary, ovary, brain etc)
  • Animal models not involved with cancer (ie: cardiac, brain, pancreas, etc.)

    These scans provide the following information:

  • Detailed 3-D anatomy
  • Perfusion
  • Capillary permeability
  • Blood volume
  • Energy metabolism
  • Metabolic markers for cancer
  • Measurements of the apparent diffusion constant
  • T1, T2 measurements

    We also provide a variety of veterinary services related to iSAIRR imaging projects including:

  • Preparation of animals for MRI experiments
  • Anesthesia and respiration
  • Physiological monitoring
  • Catheter implantation
  • Tumor implantation

For MRI experiments staff will perform the scans for users. Data analysis can be done upon request for an additional charge.