Publications | Abstracts

    2000 - 2010

    Heisen M, Fan X, Buurman J, van Riel NA, Karczmar GS, Ter Haar Romeny BM.  The use of a reference tissue arterial input function with low-temporal-resolution DCE-MRI data.  Phys Med Biol. 2010; 55:4871-83.

    Fan X, Haney CR, Mustafi D, Yang C, Zamora M, Markiewicz EJ, Karczmar GS.  Use of a reference tissue and blood vessel to measure the arterial input function in DCEMRI.  Magn Reson Med. 2010 Jul 27.

    Yang C, Stadler WM, Karczmar GS, Milosevic M, Yeung I, Haider MA.  Comparison of quantitative parameters in cervix cancer measured by dynamic contrast-enhanced MRI and CT.  Magn Reson Med. 2010; 63:1601-9.

    Medved M, Ivancevic MK, Olopade OI, Newstead GM, Karczmar GS.  Echo-planar spectroscopic imaging (EPSI) of the water resonance structure in human breast using sensitivity encoding (SENSE).  Magn Reson Med. 2010; 63:1557-63.

    Mustafi D, Fan X, Dougherty U, Bissonnette M, Karczmar GS, Oto A, Hart J, Markiewicz E, Zamora M.  High-resolution magnetic resonance colonography and dynamic contrast-enhanced magnetic resonance imaging in a murine model of colitis.  Magn Reson Med. 2010; 63:922-9.

    Heisen M, Fan X, Buurman J, van Riel NA, Karczmar GS, ter Haar Romeny BM.  The influence of temporal resolution in determining pharmacokinetic parameters from DCE-MRI data.  Magn Reson Med. 2010; 63:811-6.

    Jansen SA, Fan X, Yang C, Shimauchi A, Karczmar G, Newstead GM.  Relating dose of contrast media administered to uptake and washout of malignant lesions on DCEMRI of the breast.  Acad Radiol. 2010; 17:24-30.

    Fan X, Mustafi D, Zamora M, River JN, Foxley S, Karczmar GS.  Can DCEMRI assess the effect of green tea on the angiogenic properties of rodent prostate tumors?  Phys Med. 2010; 26:111-6.


    Jansen SA, Paunesku T, Fan X, Woloschak GE, Vogt S, Conzen SD, Krausz T, Newstead GM, Karczmar GS.  Ductal carcinoma in situ: X-ray fluorescence microscopy and dynamic contrast-enhanced MR imaging reveals gadolinium uptake within neoplastic mammary ducts in a murine model.  Radiology. 2009; 253:399-406.

    Medved M, Newstead GM, Fan X, Du YP, Olopade OI, Shimauchi A, Zamora MA, Karczmar GS.  Fourier component imaging of water resonance in the human breast provides markers for malignancy.  Phys Med Biol. 2009; 54:5767-79.

    Jansen SA, Conzen SD, Fan X, Markiewicz EJ, Newstead GM, Karczmar GS.  Magnetic resonance imaging of the natural history of in situ mammary neoplasia in transgenic mice: a pilot study.  Breast Cancer Res. 2009; 11:R65.

    Jansen SA, Shimauchi A, Zak L, Fan X, Wood AM, Karczmar GS, Newstead GM.  Kinetic curves of malignant lesions are not consistent across MRI systems: need for improved standardization of breast dynamic contrast-enhanced MRI acquisition. AJR Am J Roentgenol. 2009; 193:832-9.

    Medved M, Newstead GM, Abe H, Olopade OI, Shimauchi A, Zamora MA, Karczmar GS.  Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage. Magn Reson Imaging. 2009 Jul 21.

    Mustafi D, Peng B, Foxley S, Makinen MW, Karczmar GS, Zamora M, Ejnik J, Martin H.  New vanadium-based magnetic resonance imaging probes: clinical potential for early detection of cancer.  J Biol Inorg Chem. 2009; 14:1187-97.

    Haney CR, Parasca AD, Fan X, Bell RM, Zamora MA, Karczmar GS, Mauceri HJ, Halpern HJ, Weichselbaum RR, Pelizzari CA.  Characterization of response to radiation mediated gene therapy by means of multimodality imaging.  Magn Reson Med. 2009; 62:348-356.

    Fan X, Karczmar GS.  A new approach to analysis of the impulse response function (IRF) in dynamic contrast-enhanced MRI (DCEMRI): A simulation study.  Magn Reson Med. 2009; 62:229-239.

    Yang C, Karczmar GS, Medved M, Oto A, Zamora M, Stadler WM.  Reproducibility assessment of a multiple reference tissue method for quantitative dynamic contrast enhanced-MRI analysis.  Magn Reson Med. 2009; 61:851-9.

    Foxley S, Fan X, Mustafi D, Haney C, Zamora M, Markiewicz E, Medved M, Wood AM, Karczmar GS.  Sensitivity to tumor microvasculature without contrast agents in high spectral and spatial resolution MR images.  Magn Reson Med. 2009;  61:291-8.


    Jansen SA, Conzen SD, Fan X, Krausz T, Zamora M, Foxley S, River J, Newstead GM, Karczmar GS.  Detection of in situ mammary cancer in a transgenic mouse model: in vitro and in vivo MRI studies demonstrate histopathologic correlation. Phys Med Biol. 2008; 53:5481-5493.

    Foxley S, Fan X, Jansen SA, Zamora M, Markiewicz E, Al-Ahmadie H, Karczmar GS.  High spectral and spatial resolution MRI of age-related changes in murine prostate.  Magn Reson Med. 2008; 60:575-581.

    Jansen SA, Fan X, Karczmar GS, Abe H, Schmidt RA, Giger M, Newstead GM.  DCEMRI of breast lesions: is kinetic analysis equally effective for both mass and nonmass-like enhancement?  Med Phys. 2008; 35:3102-9.

    Foxley S, Fan X, Mustafi D, Yang C, Zamora MA, Medved M, Karczmar GS.  Quantitative analysis of water proton spectral lineshape: a novel source of contrast in MRI. Phys Med Biol. 2008; 53:4509-4522.

    Haney CR, Fan X, Parasca AD, Karczmar GS, Halpern HJ, Pelizzari CA.  Immobilization using dental material casts facilitates accurate serial and multimodality small animal imaging.  Concepts Magn Reson Part B 2008; 33B:138-144.

    Jansen SA, Fan X, Karczmar GS, Abe H, Schmidt RA, Newstead GM.  Differentiation between benign and malignant breast lesions detected by bilateral dynamic contrast-enhanced MRI: A sensitivity and specificity study.  Magn Reson Med. 2008; 59:747-754.


    Jansen SA, Newstead GM, Abe H, Shimauchi A, Schmidt RA, Karczmar GS.  Pure ductal carcinoma in situ: kinetic and morphologic MR characteristics compared with mammographic appearance and nuclear grade.  Radiology. 2007; 245:684-91.

    Yang C, Karczmar GS, Medved M, Stadler WM.  Multiple reference tissue method for contrast agent arterial input function estimation.
    Magn Reson Med. 2007; 58:1266-75.

    Fan X, Medved M, Karczmar GS, Yang C, Foxley S, Arkani S, Recant W, Zamora MA, Abe H, Newstead GM.  Diagnosis of suspicious breast lesions using an empirical mathematical model for dynamic contrast-enhanced MRI.  Magn Reson Imaging.  2007; 25:593-603.


    Fan X., Markiewicz EJ, Zamora M, Karczmar GS, Roman BB.  Comparison and evaluation of mouse cardiac MRI acquired with open birdcage, single loop surface and volume birdcage coils.  Phys Med Biol 2006; 51: N451-N459.

    Fan X, Abe H, Medved M, Foxley S, Arkani S, Zamora MA, Olopade OI, Newstead GM, Karczmar GS.  Fat suppression with spectrally selective inversion vs. high spectral and spatial resolution MRI of breast lesions: Qualitative and quantitative comparisons. J Magn Reson Imaging 2006; 24:1311-1315.

    Fan X, Medved M, Foxely S, River JN, Zamora M, Karczmar GS, Corot C, Robert P, and Bourinet P.  Multi-slice dynamic contrast-enhanced MRI using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors.  MAGMA 2006; 19:15-21.

    Fan X, River JN, Muresan AS, Popescu C, Zamora M, Culp RM and Karczmar GS. MRI of perfluorocarbon emulsion kinetics in rodent mammary tumours.  Phys Med Biol 2006; 51:211-220.

    Medved M, Newstead GM, Abe H, Zamora MA, Olopade OI, Karczmar GS. High spectral and spatial resolution MRI of breast lesions: preliminary clinical experience.  AJR Am J Roentgenol. 2006; 186:30-37.


    Du W, Fan X, Foxley S, Zamora MA, River JN, Culp RM, and Karczmar GS.  Comparison of high-resolution echo-planar spectroscopic imaging with conventional MR imaging of prostate tumors in mice.  NMR in Biomed 2005; 18:285-292.

    Du W, Karczmar GS, Uftring SJ, Du YP.  Anatomical and functional brain imaging using high-resolution echo-planar spectroscopic imaging at 1.5 Tesla.  NMR Biomed. 2005; 18:235-241.


    Roman BB, Goldspink PH, Spaite E, Urboniene D, McKinney R, Geenen DL, Solaro RJ, Buttrick PM.  Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo.  Am J Physiol Heart Circ Physiol. 2004; 286:H2089-95.

    Yang C, Karczmar GS, Medved M, Stadler WM.  Estimating the arterial input function using two reference tissues in dynamic contrast-enhanced MRI studies: fundamental concepts and simulations.  Magn Reson Med. 2004; 52:1110-1117.

    Medved M, Newstead G, Fan X, Du W, Du YP, MacEneaney PM, Culp RM, Obpade O, Zamora M, and Karczmar GS.  Fourier components of inhomogeneously broadened water resonances in breast – a new source of MRI contrast.  Magn Reson Med 2004; 52:193-196.

    Medved M, Karczmar G, Yang C, Dignam J, Gajewski TF, Kindler H, Vokes E, MacEneany P, Mitchell MT, Stadler WM.  Semiquantitative analysis of dynamic contrast enhanced MRI in cancer patients: Variability and changes in tumor tissue over time.  J Magn Reson Imaging. 2004; 20:122-8.

    Fan X, Medved M, River JN, Zamora M, Corot C, Robert P, Bourinet P, Lipton M, Culp RM, Karczmar GS.  A new model for analysis of dynamic contrast enhanced MRI data distinguishes metastatic from transplanted non-metastatic rodent prostate tumors.  Magn Reson Med 2004; 51:487-494.


    al-Hallaq HA, Zamora MA, Fish BL, Halpern HJ, Moulder JE, Karczmar GS.  Using high spectral and spatial resolution bold MRI to choose the optimal oxygenating treatment for individual cancer patients.  Adv Exp Med Biol. 2003; 530:433-440.

    Medved M, Du W, Zamora M, Fan X, Olopade O, MacEneaney PM, Newstead G, Karczmar GS.  The effect of varying spectra resolution on the quality of HiSS MR images of the breast.  J Magn Reson Imaging 2003; 18:442-448.

    Du W, Du YP, Fan X, Zamora MA, Karczmar GS.  Reduction of spectral ghost artifacts in high resolution echo-planar spectroscopic imaging of water and fat resonances.  Magn Reson Med 2003; 49:1113-1120.


    Roman BB, Meyer RA, Wiseman RW.  Phosphocreatine kinetics at the onset of contractions in skeletal muscle of MM creatine kinase knockout mice.  Am J Physiol Cell Physiol. 2002; 283:C1776-83.

    Fan X, River JN, Zamora M, Al-Hallaq H, Karczmar GS.  Effect of carbogen on tumor oxygenation: Combined fluorine-19 and proton MRI measurements.  Int J Radiat Oncol Biol Phys 2002; 54:1202-1209.

    Fan X, Du W, Zamora M, MacEneaney PM, Karczmar G.  Structure of the water resonance in small voxels in rat brain detected with high spectral and spatial resolution MRI.  J Magn Reson Imaging 2002; 16:547-552.

    Du W, Karczmar GS, Pan X.  Effects of constant frequency noise in magnetic resonance imaging with nonuniform k-space sampling.  Med Phys. 2002; 29:1832-1838.

    Karczmar GS, Du W, Medved M, Bick U, MacEneaney P, Du YP, Fan X, Zamora M, Lipton M.  Spectrally inhomogeneous effects of contrast agents in breast lesion detected by high spectral and spatial resolution MRI.  Acad Radiol 2002; 9(suppl 2):S352-S354.

    Du W, Du YP, Bick U, Fan X, MacEneaney PM, Zamora MA, Medved M, Karczmar GS.  Breast MR imaging with high spectral and spatial resolutions: Preliminary experience.  Radiology 2002; 224:577-585.

    Karczmar GS, Fan X, Al-Hallaq H, River JN, Tarlo K, Kellar K. Zamora M, Rinker-Schaeffer C, Lipton MJ.  Functional and anatomic imaging of tumor vasculature: high-resolution MR spectroscopic imaging combined with a superparamagnetic contrast agent.  Acad Radiol 2002; 9(suppl 1):S115-118.

    Al-Hallaq HA, Fan X, Zamora M, River JN, Moulder JE, Karczmar GS.  Spectrally inhomogeneous BOLD contrast changes detected in rodent tumors with high spectral and spatial resolution MRI.  NMR Biomed. 2002;15:28-36.


    Roman BB, Geenen DL, Leitges M, Buttrick PM.  PKC-beta is not necessary for cardiac hypertrophy.  Am J Physiol Heart Circ Physiol. 2001; 280:H2264-70.

    Fan X, River JN, Zamora M, Tarlo K, Kellar K, Rinker-Schaeffer C, Karczmar GS.  Differentiation of non-metastatic and metastatic rodent prostate tumors with high spectral and spatial resolution MRI.  Magn Reson Med 2001; 45:1046-1055.


    Al-Hallaq HA, Zamora M, Fish BL, Farrell A, Moulder JE, Karczmar GS.  MRI measurements correctly predict the relative effects of tumor oxygenating agents on hypoxic fraction in rodent BA1112 tumors.  Int J Radiat Oncol Biol Phys. 2000; 47:481-488.

    Karczmar GS, Fan X, Al-Hallaq H, Zamora M, River JN, Rinker-Schaeffer C, Zaucha MM, Tarlo K, Kellar K.  Uptake of a superparamagnetic contrast agent imaged by MR with high spectral and spatial resolution.  Magn Reson Med 2000; 43:633-639.


    1994 - 1999

    Slawson SE, Roman BB, Williams DS, Koretsky AP.  Cardiac MRI of the normal and hypertrophied mouse heart.  Magn Reson Med. 1998; 39:980-7.

    Kovar DA, Lewis M, Karczmar GS.  A new method for imaging perfusion and contrast extraction fraction: input functions derived from reference tissues.  J Magn Reson Imaging. 1998; 8:1126-1134.

    Al-Hallaq HA, River JN, Zamora M, Oikawa H, Karczmar GS.  Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation.  Int J Radiat Oncol Biol Phys. 1998; 41:151-159. 

    Kovar DA, Al-Hallaq HA, Zamora MA, River JN, Karczmar GS.  Fast spectroscopic imaging of water and fat resonances to improve the quality of MR images.  Acad Radiol. 1998; 5:269-275.


    Kovar DA, Lewis MZ, River JN, Lipton MJ, Karczmar GS.  In vivo imaging of extraction fraction of low molecular weight MR contrast agents and perfusion rate in rodent tumors.  Magn Reson Med. 1997; 38:259-268.

    Oikawa H, al-Hallaq HA, Lewis MZ, River JN, Kovar DA, Karczmar GS.  Spectroscopic imaging of the water resonance with short repetition time to study tumor response to hyperoxia.  Magn Reson Med. 1997; 38:27-32.


    Roman BB, Foley JM, Meyer RA, Koretsky AP.  Contractile and metabolic effects of increased creatine kinase activity in mouse skeletal muscle.   Am J Physiol. 1996; 270(4 Pt 1):C1236-45.

    Kuperman VY, Karczmar GS, Blomley MJ, Lewis MZ, Lubich LM, Lipton MJ.  Differentiating between T1 and T2* changes caused by gadopentetate dimeglumine in the kidney by using a double-echo dynamic MR imaging sequence.  J Magn Reson Imaging. 1996; 6:764-768.

    Kovar DA, Lipton MJ, Lewis MZ, River JN, Lubich L, Karczmar GS.  Dynamic contrast measurements in rodent model tumors.  Acad Radiol. 1996; 3 Suppl 2:S384-S386.


    Kuperman VYu, River JN, Lewis MZ, Lubich LM, Karczmar GS.  Changes in T2*-weighted images during hyperoxia differentiate tumors from normal tissue.  Magn Reson Med. 1995; 33:318-325.

    Karczmar G, River J, Koretsky AP.  Radiofrequency magnetic field gradient echoes have reduced sensitivity to susceptibility gradients. Magn Reson Imaging. 1995;13:791-797.


    Karczmar GS, Kuperman VY, River JN, Lewis MZ, Lipton MJ.  Magnetic resonance measurement of response to hyperoxia differentiates tumors from normal tissue and may be sensitive to oxygen consumption.  Invest Radiol. 1994; 29 Suppl 2:S161-S163.

    Karczmar GS, River LP, River J, Kovar D, Lewis MZ, Lee RC, Lipton MJ.  Prospects for assessment of the effects of electrical injury by magnetic resonance. Ann N Y Acad Sci. 1994; 720:176-180.

    Karczmar GS, River JN, Li J, Vijayakumar S, Goldman Z, Lewis MZ.  Effects of hyperoxia on T2* and resonance frequency weighted magnetic resonance images of rodent tumours.  NMR Biomed. 1994; 7(1-2):3-11.

    Karczmar GS, River JN, Goldman Z, Li J, Weisenberg E, Lewis MZ, Liu K.  Magnetic resonance imaging of rodent tumors using radiofrequency gradient echoes.  Magn Reson Imaging. 1994; 12:881-93.